http://area1255.blogspot.com/2013/06/exclusive-what-how-of-dht.html EXCLUSIVE : The What & The How of DHT (Dihydrotestosterone) in the Brain Many bodybuilders and fitness enthusiasts are going to be thrilled to find out how exactly DHT works in the Brain. What does it do for us there ? Is it really responsible for libido, and if so, what other chemicals does it affect? This article aims to surpass and explain the general knowledge floating around on the Internet and on Forums. I am not a doctor, but I have compiled a nice bunch of references and studies to cite the foundation of this article. I also will explain briefly (an estimate) how someone would feel based on the relative changes due to DHT - discussed in this article. First off, a basic explanation of DHT (Dihydrotestosterone); it is an androgen (male sex hormone), like Testosterone, which rather than promoting the growth of muscle mass directly (tissue-acting), it acts via intracellular (in the cell) mechanisms to increase strength and metabolism. DHT is not very anabolic, but it is Androgenic, and thus meaning, it promotes masculine characteristics (such as a deeper voice, and growth of facial hair, body hair etc) (1). DHT has a bad rap, since it has been claimed to cause an enlarged prostate, but if you follow the source, *most* of the studies saying this are linked to pharmaceutical promotion of their anti-prostate, anti-Male drug, Finasteride (Propecia) and Dustasteride(2) (3). DHT has also been claimed to cause your hair follicles to become thin, and your hair - subsequently falls out. No. Just No. DHT has been implicated as a factor at most, more studies show that more specifically it is Zinc deficiency AND genetics that provoke male pattern baldness (4)(5). Although Zinc deficiency causes the rise of DHT levels, it also causes increases in prolactin, and estrogen, thus the real problem here *could* have to do with either of those hormones. Just to clarify, Anti-ESTROGEN drugs have been used recently to treat prostate enlargement (BPH), and they are very successful, with less side-effects(6) (7) (8) (9). So if they were wrong about DHT causing prostate enlargement, maybe they were wrong about DHT and hair loss too. DHT - HOW IT AFFECTS THE BRAIN - AND NERVOUS SYSTEM But anyway, we got carried away. Let's go on to discuss DHT's effects in the Brain. DHT has pronounced effects on neurochemistry (it affects neurotransmitters in the brain). DHT has been shown to increase circulating epinephrine levels (adrenaline), this can cause anxiety in predisposed individuals, however, most of the time, this is not the case, since DHT also increases GABA activity in the brain, which is relaxing (10) (11) (12). So in other words, DHT should promote A focused, calm burst of energy, which is what many users of DHT-based steroids, report as the "alpha-male" feeling (13) (14). Dihydrotestosterone increase central and nervous system energy production by increasing not just adrenaline, but cyclic AMP (15). This molecule increase thermogenesis (fat-burning and heat production)(16). Cyclic AMP facilitates the conversion of TSH thyroid hormone, to T4, a more potent thyroid hormone, thus, indirectly, DHT increases thyroid function (by increasing cyclic AMP) (17). So seeing all this, DHT definitely acts as a nervous system stimulant, and a metabolic "probe", it also increases GABA. Second to this though, it could indirectly decrease serotonin or serotonin receptors; since DHT antagonizes estrogen activity, and estrogen helps maintain the expression of serotonin receptors in the brain(18) (19). This is also consistent with DHT being shown to stop estrogen induced prolactin release(20). This is part of the reason behind using DHT Gel to treat gynecomasita. Clearly DHT has anti-depressant effects, since Finasteride causes depression (21) and also based on the above mentioned activity of DHT in the brain. It gives energy, it gives focus, it gives aggression.